Category Archives: CFRD FactsInteresting tidbits about CFRD: Diabetic ketoacidosis (DKA) is rare. (I would love some more info on this). Pancreatic insufficiency associated with CFRD. A1c levels may underestimate abnormal glucose metabolism. (would love more info on this too). So far I have only found that there is an increased red cell turnover, causing a “diluted” A1c level. [...]
Autoimmune induced insulin deficiency is the cause of type 1 diabetes. Insulin deficiency in CFRD is due to scarring and destruction of the pancreatic islet cells and their beta cells (the insulin producers). CFRD is not associated with the autoimmune process and the autoantibodies seen in Type 1 diabetes Scarring (fibrosis) occurs due to thickened [...]
Not Type 1 or Type 2 CFRD is most like type 2 diabetes, BUT requires insulin treatment like type 1 diabetes rather than diet and oral therapy like type 2. Reasoning: Caloric intake needs to be maintained to meet metabolic demands of CF Oral medications used in type 2 diabetes can not be used in [...]
CFRD is the most common co-morbid complication of Cystic Fibrosis patients. The prevalence of CFRD increases with age 14% of CF patients > 13 years old 25% of CF patients 35-44 years old approximately 43% of Cystics > 30 years old
Factors unique to Cystic Fibrosis: Under nutrition Chronic inflamation with intermittent acute infection Glucagon* deficiency Altered gut nutrient absorption and transit time Liver disease Increased energy expenditure Thin, low lipid levels, normal blood pressure What does this mean? Under nutrition – Under nutrition makes it more important for Cystics to get all the nutrition their [...]
In 2003, 16.9% of Cystics > 13 years old in the US have CFRD requiring insulin therapy. Assuming a population of 21,742 Cystics (in 2003) seen at CF care centers in the US, this equals approximately 3,675 patients.
After compiling several days worth of CFRD facts, I decided I am not going to post one every single day. Honestly, I find it too depressing. They are important facts, but I will sprinkle them throughout time rather than dumping them all at once.
CFRD patients, as compared to Cystics without diabetes, are more likely to be underweight and to have severe pulmonary disease.
I am going to start posting a few facts a day about CFRD. Keep checking back for more info! Todays fact: There are approximately 22,000 Cystics in the Cystic Fibrosis Foundation Patient Registry. Using this registry it has been found that there is a 6-fold mortality rate in CFRD patients compared to Cystics without diabetes.
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