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CFRD Fact #14

Complications of CFRD (poorly controlled):
Infections due to decreased white blood cell count phagocystosis.

Phagocystosis is the ability to encourage white blood cells to destroy bacteria.

Increased viscosity of mucus secretions with hyperglycemia and dehydration.

Dehydration is caused by the body trying to flush the excess blood glucose out in the urine.

Increased protein catabolism with CF [...]

CFRD Fact #12

How might early diabetes cause CF clinical decline? It is currently unknown, but here are some theories:

Insulin Deficiency

Insulin is an anabolic hormone which promotes conservation of body protein, fat and carbohydrate stores.

Malnutrition and protein catabolism are clearly associated with death in CF.